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Polycaprolactone innovative stimulator - Why is it a Game Changer?

Dermal fillers have become popular for its ability to naturally rejuvenate the skin - leading to innovative technology of its main component, namely PCL. But, what is it and why is it a game changer?

Gone are the days where a surgical knife is needed to uplift sagging and wrinkly skin.

Advancements in the field of aesthetics has made it possible for physicians to deliver results comparable to surgical procedures – if not better – that are non-invasive and long-lasting. How? The simple answer is, collagen-stimulating dermal fillers.

This step forward has not only made this treatment more sought-after, it has led to cutting-edge innovation of its components and application. One new revolutionary ingredient that has been developed is, Polycaprolactone, clinically known as PCL.


What is PCL?

PCL is a type of micro-sphere polymer and the main component in advanced fillers. It is bioresorbable and biocompatible, meaning it is easily absorbed into the skin and binds well when in contact with human tissues and fluids. Extensive studies have also concluded that PCL is safe when injected into the dermal layer, and naturally dissolves without harming the internal skin tissue. Its high safety profile is CE marked, meaning it meets European Union standards for health and safety within the aesthetics and pharmaceutical industries.

PCL is usually administered into the skin suspended in a soft gel, known as, carboxymethylcellulose (CMC). As it’s injected into the skin, the CMC gel immediately fills up the volume-deficient areas, allowing the PCL microspheres to stimulate collagen production within 3 to 6 months, ultimately replacing the dissolving CMC gel. The end result is naturally lifted, tight and volumised skin.

Why is PCL a Game Changer?

Bestowed as the ‘innovative stimulator,’ PCL’s best feature is that it stimulates natural collagen within the dermal layer. This means, it not only helps to reduce fine lines and wrinkles, it also restores loss of volume over time.

As you age, you lose facial fat and collagen, the chemical which keeps the skin moist, full and youthful looking. Simply put, facial volume loss happens when the face fat that was once evenly distributed around the eyes, cheeks, forehead, temples, and mouth shifts and diminishes. Cheeks fall downward and sink, Lips begin to lose their plumpness and jawlines begin to sag. This is where the PCL innovative stimulator comes into play!

Basically PCL takes advantage of the body’s natural process of producing skin collagen – a process known as ‘Neocollagenesis.’ The micro-sphere polymers induce this natural mechanism to progressively restore the youthful and toned look of the skin. It is also gradually absorbed by the body over time, leaving behind your natural, renewed network of collagen.

PCL-based fillers also has a list of other benefits that tops most other fillers currently available in the market. One being that, it delivers instant results just after one session. Besides that, PCL-based fillers can last for a much longer period, from between 2 to 4 years, compared to traditional fillers that last for only 12 to 18 months.

The Evidence of Long-Term Efficacy of the PCL innovative stimulator

There were several clinical studies done to assess the efficacy and duration of lasting results produced by the PCL innovative stimulator; Patients were injected with PCL-based fillers and observed for 6 to 24 months. The observation evaluated the effect of PCL on nasolabial folds or what is commonly known as ‘laugh lines’ – the indentation lines on either side of the mouth that extend from the edge of the nose to the mouth's outer corners. The efficacy of the PCL-based filler was assessed based on the Wrinkle Severity Rating Scale (WSRS) and the Global Aesthetic Improvement Scale (GAIS) – by subjects and investigators and on the basis of photos. The results turned out to be very satisfying, as recorded by the patients and investigators, with outcomes on GAIS showing improvement in 90% of patients.

Conclusion: How the PCL innovative stimulator has changed the game for good

Polycaprolactone (PCL), is a well-known microsphere polymer with several specific and leading-edge qualities – it is biocompatible, slowly biodegradable and bioresorbable. In the world of aesthetics, PCL has been introduced as an innovative and revolutionary collagen-stimulator for facial rejuvenation. It exerts dual action with immediate volumising by the CMC gel and sustained collagen production by the microspheres. Moreover, the long-lasting effects as well as the safety of the PCL-filler has also been confirmed in clinical studies and by clinical practices worldwide for the past 10 years. Ultimately, the PCL innovative stimulator, is a non-invasive treatment that restores volume, reshapes and rejuvenates the face, providing long-lasting natural results and overall skin improvement.

Keen to know more about the PCL innovative stimulator? Check out the top questions frequently asked by Singaporeans, about the most popular PCL-based collagen-stimulating treatment.


  1. https://www.dovepress.com/polycaprolactone-how-a-well-known-and-futuristic-polymer-has-become-an-peer-reviewed-fulltext-article-CCID
  2. https://onlinelibrary.wiley.com/doi/full/10.1111/jocd.12482

3. https://issuu.com/austramedex/docs/ellanse_physicians_brochure_va01cro